DOSAGE AND ADMINISTRATION

Safety and efficacy have not been established

in patients with PAH younger than 1 year.

Pregnancy & Lactation

Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms such as low sex drive, erectile dysfunction (ED), and fatigue because the body doesn’t produce enough testosterone. Though many men don’t like to talk about it, ejaculation problems are very common. Some of the most common issues include premature, delayed, or retrograde ejaculation. Your pelvic floor is a lot like plumbing in your home: you never really think about it unless something goes wrong. When you think of male sexual dysfunction, concerns like erectile dysfunction (ED) or premature ejaculation (PE) probably come to mind first.

Before taking sildenafil,

But there’s another sex-related issue that’s more common in men than you might expect: difficulty orgasming. DescriptionDosage FormTabletStrength20 mgIndicationPulmonary Arterial hypertensionBrand NameRevatio®TE CodeABLactoseNoGlutenNoColorWhiteShapeCircular, biconvexMarkingsDebossed with ‘SC’ on one side and ’20’ on other sideStorage ConditionStore at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Pack Size: 90sNDC#: 27241-0124-03Click to View Package Insert Click to View Material Data Safety Sheet Revatio ® is registered trademark of Pfizer Applies to the following strengths: 10 mg/mL; 10 mg/12.5 mL; 20 mg; 25 mg; 50 mg; 100 mg; 75 mg TABLETS (Viagra) Initial dose: 50 mg orally once a day, as needed, about 1 hour prior to sexual activity Maintenance dose: May increase to 100 mg or decrease to 25 mg once a day, based on efficacy and tolerability. Maximum dose: 100 mg orally once a day Comments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity. TABLETS (Revatio)/ORAL SUSPENSION (Revatio, Liqrev): Initial dose: 20 mg orally 3 times a day Maintenance dose: May titrate up to 80 mg orally 3 times a day, if required, based on symptoms and tolerability. Maximum dose: 80 mg orally 3 times a day IV: 10 mg IV bolus 3 times a day Comments: No adjustment for body weight is required for IV dosing. Due to high plasma protein binding and poor

• Sildenafil 20 mg tablets are supplied in blister packs or bottles.
• Always check the expiration date before use.
• Alcohol may reduce the effectiveness or increase side effects.
• Avoid taking sildenafil with fatty foods for faster absorption.
• Keep out of reach of children to prevent accidental ingestion.

elimination in urine, removal

via hemodialysis is unlikely.

Proper Use

The 10 mg IV bolus dose is predicted to provide an equivalent pharmacological effect to that of 20 mg orally. Doses up to a maximum of 80 mg orally 3 times a day are supported by delayed clinical worsening with long-term use in clinical studies despite a lack of observed dose-response improvement in exercise ability in short-term clinical studies. In adults 65 years or older, use caution with dose selection due to a higher incidence of compromised renal, cardiac, and/or hepatic function, and of concomitant disease or drug therapy. Use: For the treatment of PAH (WHO Group I) to improve exercise ability and delay clinical worsening TABLETS (Viagra) Initial dose: 25 mg orally once a day, as needed, about 1 hour prior to sexual activity Maintenance dose: May titrate up to 100 mg orally once a day, based on effectiveness and toleration. Maximum dose: 100 mg orally once a day Comments: This drug may be administered anywhere from 30 minutes to 4 hours before sexual activity. Tablets: Administer orally with or without food.

6.2 Postmarketing Experience

Sildenafil can interact with the nitrites found in certain recreational drugs popularly known as “poppers,” causing a dangerous drop in blood pressure. Don’t mix sildenafil with other ED drugs, like Cialis®, Levitra®, Revatio® (another brand name for sildenafil) or Stendra®. This can put you at risk for low blood pressure. More of something isn’t always better! Aside from heart medications and other PDE5 inhibitors, taking sildenafil with ritonavir, ketoconazole, itraconazole, or clarithromycin (an antibiotic) can increase the concentration of sildenafil in your body and make you more likely to experience side effects.

Less common

Talk with a healthcare professional before mixing sildenafil with over-the-counter supplements, which aren’t regulated in the same way as prescription drugs. Learn more about health and drug interactions in our sildenafil interactions guide. If you’re living with ED symptoms, you’re not alone. Sildenafil can make it easier to get and keep an erection so you can enjoy a fulfilling sex life. Here’s what to remember when taking sildenafil for ED: Take it at least 30 to 60 minutes and no more than four hours before sexual stimulation. Reconstitute product before oral administration,

What special dietary instructions should I follow?

Don’t be tempted to use expired medicines. Gianmarco Troiano & Giacomo Lazzeri (2021) The potential toxic combination of grapefruit juice and sildenafil, Toxin Reviews, 40:3, 334-337. Sildenafil citrate induced retinal toxicity-electroretinogram, optical coherence tomography, and adaptive optics findings. Do food and dose timing affect the efficacy of sildenafil? Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current.

The Bottom Line

We rely on peer-reviewed studies, academic research institutions, and medical associations. We sildenafil citrate sublingual tablets 100mg strive to use primary sources and refrain from using tertiary references. Erectile dysfunction is a condition in which you have trouble getting or keeping an erection firm enough for satisfying sex. Erectile dysfunction affects as many as 30 million men in the United States. Premature ejaculation (PE) is a sexual dysfunction characterized by a short ejaculatory latency, a perceived lack of control about the timing of ejaculation, and distress and interpersonal difficulty related to ejaculating too quickly. and shake well before use.

• Sildenafil 20 mg can interact with nitrates used for chest pain.
• Store tablets at room temperature, away from moisture.
• Do not crush or split the tablets; swallow whole.
• It is not recommended for use by women or children.
• Known for its rapid onset, usually within 30 minutes.

An oral syringe is recommended

How do you want your item?

Also, avoid high-fat foods or meals that can slow absorption. Take it at least 30 to 60 minutes and no more than four hours before sexual stimulation. Don’t mix sildenafil with medications that can cause dangerous interactions. Unsure whether your meds are safe to combine with sildenafil? Regular exercise, a balanced diet, and quality sleep can maximize your overall health and sexual well-being.

Dosage for erectile dysfunction (ED)

Consider alternative treatments if sildenafil doesn’t work for you. Other oral erectile dysfunction medications include tadalafil (generic for Cialis), avanafil (Stendra), vardenafil, and chewable Hard Mints. Your healthcare provider might also recommend adjusting your sildenafil dosage. Ready to find an erectile dysfunction treatment that works for you? Get advice from one of our healthcare providers to learn more about your options. for dose measurement (and delivery).

In case of emergency/overdose

Recommended dose: 25 mg orally, as needed, about 1 hour prior to sexual activity Maximum dose: 25 mg orally within a 48 hour period Known hypersensitivity to either the active component or to any of the ingredients; hypersensitivity reactions have been reported, including rash and urticaria In patients who are using a guanylate cyclase (GC) stimulators, such as riociguat; phosphodiesterase type 5 inhibitors (PDE5), including this drug, may potentiate the hypotensive effects of GC stimulators. In patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently; this drug has been shown to potentiate the hypotensive effects of nitrates based on its mechanism of action After patients have taken this drug for ED, it is unknown when nitrates, if necessary, can be safely administered. Although plasma levels of this drug at 24 hours post-dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point. Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of hypotension Concomitant use of riociguat, a guanylate cyclase stimulator; PDE5 inhibitors, including this drug, may potentiate the hypotensive effects of riociguat. Known hypersensitivity to either the active component or to any of the ingredients of the tablet, injection, or oral suspension; hypersensitivity reactions have been reported, including anaphylactic reaction, anaphylactic shock, and anaphylactoid reaction Safety and efficacy have not been established in patients with ED younger than 18 years. Use within 60 days after

reconstitution; discard any remainder after expiration.

6.2 Post-marketing Experience

A reduced starting dose is sildenafil film tablet recommended in older adults due to higher systemic exposure as compared to younger adults. TABLETS (Revatio)/ORAL SUSPENSION (Revatio) 1 to less than 18 years: Weight 20 kg or less: 10 mg orally 3 times a day Weight greater than 20 kg to 45 kg: 20 mg orally 3 times a day Weight greater than 45 kg: 20 mg orally 3 times a day; dose may be titrated up to a maximum of 40 mg orally 3 times a day, if required, based on symptoms and tolerability Use: For the treatment of pulmonary arterial hypertension (WHO Group I) to improve exercise ability and, in pediatric patients too young to perform standard exercise testing, pulmonary hemodynamics thought to underlie improvements in exercise ERECTILE DYSFUNCTION: Mild to Moderate Renal Dysfunction (CrCl 30 to 80 mL/min): No adjustment recommended Severe Renal Dysfunction (CrCl less than 30 mL/min): Consider a starting dose of 25 mg orally once a day, about 1 hour prior to sexual activity Mild, Moderate, or Severe Renal Dysfunction (CrCl 80 to less than 30 mL/min): No adjustment recommended ERECTILE DYSFUNCTION: Mild, Moderate, or Severe Liver Dysfunction (Child-Pugh A, B, or C): Consider a starting dose of 25 mg orally once a day, about 1 hour prior to sexual activity. Mild or Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended Severe Liver Dysfunction (Child-Pugh C): Data not available in this population. Initiate treatment with 25 mg orally once a day, as needed, about 1 hour prior to sexual activity Patients should be stable on alpha blocker therapy prior initiating treatment with this drug. Administration with CYP450 3A4 Inhibitors (e.g., ketoconazole, itraconazole, saquinavir) or Erythromycin: Consider a starting dose of 25 orally once a day, as needed, about 1 hour prior to sexual activity.